NCAA Football: Houston at Oklahoma
Kevin Jairaj / USA TODAY Sports

Texas Tech and Houston face off as part of Saturday's massive college football slate. There's plenty of history to draw on in this in-state rivalry game, and both sides hope to bounce back from disappointing 2020 campaigns. The Cougars have won one of their previous five meetings with the Red Raiders. Can they turn the tide on Saturday?

Kickoff at Jones AT&T Stadium is set for 7 p.m. ET. The Cougars are 2.5-point favorites in the latest Texas Tech vs. Houston odds at Caesars Sportsbook. The over-under is set at 64. Before making any Texas Tech vs. Houston picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Houston vs. Texas Tech. You can head to SportsLine to see its picks. Here are several college football odds for Texas Tech vs. Houston:

  • Houston vs. Texas Tech spread: Houston -2.5
  • Houston vs. Texas Tech over-under: 64 points

What to know about the Texas Tech Red Raiders

Texas Tech has been dominant against Houston in recent years. The Red Raiders 4-1 record against the Cougars since 1992 speaks to that. Texas Tech only fell short by one point in its lone road loss to Houston during that span. The Red Raiders' defense can carry them to a fourth straight win against the Cougars.

Colin Schooler is the NCAA's active leader in tackles and tackles for a loss. He'll spearhead Texas Tech's linebacker group and wreak havoc against the Cougars. The Red Raiders' ability to force turnovers by applying pressure to the quarterback could help them cover.

What to know about the Houston Cougars

The Cougars played about as tough of a truncated schedule as you can playing outside of a Power Five conference a season ago, hosting BYU and UCF while also visiting Cincinnati and Memphis. However, that's not going to earn coach Dana Holgorsen a lot of sympathy after he was given a five-year, $20 million contract to make Houston competitive on the national stage.

Tune returns at quarterback after throwing for 2,048 yards and 15 touchdowns a season ago, while also adding 253 yards on the ground and five rushing touchdowns. He'll have leading receiver Nathaniel Dell back as well after he caught 29 passes for 428 yards and three touchdowns. The defense should also be improved with several starters expected back including pass-rushing ace David Anenih.

How to make Texas Tech vs. Houston picks

The model has simulated Houston vs. Texas Tech 10,000 times and the results are in. It is leaning under on the total and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Texas Tech vs. Houston? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.